Multi-visit Advanced Pediatric Brain Imaging (MAP)

Research Summary

The MAP study is a collaborative project with Cohen lab

Brain development in the first years of life is the most dynamic and perhaps the most important phase of postnatal brain development. However, infant longitudinal neuroimaging studies rarely go beyond the age of two years in order to link early brain development to later brain development and cognitive outcomes. In this study, we are utilizing structural and functional Magnetic Resonance Imaging (MRI) to document brain development from birth to middle childhood (8-10 years) to understand how the brain grows and matures. This study involves MRI scanning of a densely-sampled longitudinal sample from birth to 8-10 years to identify how trajectories of brain development predict behavior (cognitive tasks, neuropsychological assessment, and academic outcomes) in children at 8-10 years. Using network analysis of longitudinal cortical change, we have found that integrated brain network maturation throughout infancy and childhood predicted later working memory (Woodburn et al., Under review). We have also revealed different patterns of functional network organization that supported current working memory (Woodburn et al., Flux 2020) and delayed visual memory function at 8-10 years (Bricken et al., Flux 2020).

Papers:

Mackenzie Woodburn, John Hession, Cheyenne Bricken, Weili Lin, Margaret A. Sheridan, & Jessica R. Cohen. Neural development of face recognition specialization from infancy to childhood. Virtual poster presented at 2021 Society for Research on Child Development. Minneapolis, MN

Mackenzie Woodburn, Margaret Sheridan, Cheyenne Bricken, Weili Lin, & Jessica R. Cohen. Reconfiguration of functional brain networks from resting-state to task during childhood is associated with motor learning and working memory. Virtual poster presented at 2020 Flux: Society for Developmental Cognitive Neuroscience. Santa Rosa, CA

Cheyenne Bricken, Margaret A. Sheridan, Mackenzie Woodburn, Weili Lin, & Jessica R. Cohen. Brain network organization and cognitive performance during childhood. Virtual poster presented at 2020 Flux: Society for Developmental Cognitive Neuroscience. Santa Rosa, CA

Mackenzie Woodburn, Margaret Sheridan, Cheyenne Bricken, Weili Lin, & Jessica R. Cohen. Trajectories of group and individual-level structural brain network organization from birth to childhood and their cognitive relevance. Poster presented at 2019 Flux: Society for Developmental Cognitive Neuroscience. New York, NY

Cheyenne Bricken, Jessica R. Cohen, Daniel Bauer, Mackenzie Woodburn, Weili Lin, & Margaret Sheridan. Longitudinal trajectories of cortical thickness from birth to 6 years predict cognitive outcomes at 9 years. Poster presented at 2019 Flux: Society for Developmental Cognitive Neuroscience. New York, NY

Mackenzie Woodburn, Jessica Cohen, and Weili Lin. Early developmental trajectories of structural brain networks. Poster presented at 2018 Smokies Cognition and Neuroscience Symposium (SCANS). Asheville, NC

Mackenzie Woodburn, Cheyenne Bricken, Zhengwang Wu, Gang Li, LI Wang, Weili Lin, Margaret A. Sheridan, & Jessica R. Cohen. The maturation and cognitive relevance of structural brain network organization from birth to childhood. Under Review.